Exhibit 99.1

LOGO

For Immediate Release

Investors:

David K. Waldman or Klea K. Theoharis

Crescendo Communications, LLC

Tel: (212) 671-1020

InfuSystem Holdings Reports $9.2 Million of Revenue and

45% Increase in Adjusted EBITDA for the First Quarter of 2009

Madison Heights, Michigan—May 5, 2009 – InfuSystem Holdings, Inc. (OTCBB: INHI; INHIW; INHIU), the leading provider of ambulatory infusion pumps and associated clinical services, today announced financial results and provided a business update for the first quarter ended March 31, 2009.

Mr. Steve Watkins, chief executive officer, commented, “We achieved $9.2 million of revenue during the first quarter of 2009, despite a nationwide shortage of Leucovorin, a compound frequently used in association with ambulatory pump chemotherapy, which has since been resolved. At the same time, we increased gross margins by 560 basis points and continue to gain operating leverage as we held our costs in line. As a result, we generated $2.9 million of adjusted EBITDA, a 45% increase compared to the first quarter of 2008. This contributed to the Company’s continued strong operating cash flow and ample cash reserves, allowing us to improve the balance sheet by aggressively paying down debt. Shortly following the first quarter, we made a $5.3 million payment on our term loan, resulting in the Company having lowered its term loan balance by over $6.1 million year-to-date.”

Mr. Watkins concluded, “We remain encouraged by the near- and long-term outlook for the ambulatory infusion services market. Drug companies are incorporating continuous infusion as part of their drug treatment regimens and promoting these to oncologists. The American Cancer Society estimated that there were about 148,810 new cases of colorectal cancer in 2008 in the United States. Moreover, the combined benefits to the patient, physician and insurance provider support the expanded use of ambulatory infusion pumps to administer chemotherapy beyond stage III colorectal cancer, including esophageal, head and neck, gastric and other cancers. In order to best capitalize on this market opportunity, we continue to enhance our sales organization, including the recent addition of Bryan Russo as chief commercial officer. We look forward to his contributions as we focus on accelerating and deepening our penetration of oncology practices nationwide. Looking ahead, we anticipate continued organic revenue growth, greater operational efficiencies, and continued strong cash flow to allow for paying down additional debt in 2009.”


Financial Results

Revenue for the first quarter ended March, 31 2009 was $9.2 million, an 8.2% improvement compared to $8.5 million for the same period in 2008. The increase in revenue was primarily due to obtaining business at new customer facilities, increased reimbursement, as well as improved collection efficiencies. Operating income for the first quarter of 2009 was $1.3 million versus operating income of $521,000 for the same period in 2008. The increase in operating income for the first quarter of 2009 was due, in part, to increased sales and lower product and supply costs, which were partially offset by an increase in selling and marketing expenses.

The net loss for the first quarter of 2009 was ($2.5 million), or $(0.14) per diluted share, compared to net income of $4.8 million or $0.29 per diluted share, for the same period in 2008. The net income for the first quarter of 2009 included a ($2.6 million) loss on derivative financial instruments, which was predominantly attributable to the increase in the publicly traded value of the Company’s warrants during the quarter, compared to a $5.2 million gain for the first quarter of 2008.

Adjusted EBITDA for the first quarter ended March 31, 2009 was $2.9 million, compared to $2.0 million for the same period in 2008. The Company defines Adjusted EBITDA as earnings before interest, taxes, depreciation and amortization, and excludes gain (loss) on derivative financial instruments and stock-based compensation. Adjusted EBITDA is not a measure of performance calculated in accordance with generally accepted accounting principles in the United States (“GAAP”). The Company believes the presentation of Adjusted EBITDA is a relevant and useful measure to assist a reader’s ability to understand the Company’s operating performance. The Company’s management likewise utilizes Adjusted EBITDA as a means to measure its operating performance. The table below reconciles Adjusted EBITDA, a non-GAAP measure, to net income.

 

     Three Months Ended  

Reconciliation from Net Income to Adjusted EBITDA:

   March 31  
   2009     2008  

Net Income

   $ (2,507 )   $ 4,797  

Adjustments:

    

Interest expense

     989       958  

Interest income

     (3 )     (3 )

Income tax expense

     140       —    

Depreciation – Pumps

     840       963  

Depreciation – Other

     32       41  

Amortization

     457       457  
                

EBITDA

   $ (52 )   $ 7,213  
                

Adjustments:

    

Loss (gain) on derivatives

     2,642       (5,231 )

Stock based compensation

     278       —    
                

Adj. EBITDA

   $ 2,868     $ 1,982  
                


About InfuSystem Holdings, Inc.

InfuSystem is the leading provider of ambulatory infusion pumps and associated clinical services for oncology practices and their patients in the U.S. These pumps allow for the gradual delivery of a drug over a period of days in the privacy of one’s home, compared to bolus infusion chemotherapy treatments that are given in a single high dose over a short period of time. Improved efficacy of the drugs, patient comfort, reimbursement to doctors for appropriate services and continuity of care all play a role in the growing trend toward this form of treatment. InfuSystem’s pumps are primarily used for colorectal cancer, but they have been approved for other forms of cancer, thereby greatly enhancing the market opportunity for InfuSystem.

Forward-Looking Statements

Except for the historical information contained herein, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties that could cause actual results to differ materially from those predicted by such forward-looking statements. These risks and uncertainties include general economic conditions, as well as other risks detailed from time to time in InfuSystem’s publicly filed documents.

(Tables follow)


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED BALANCE SHEETS

 

(in thousands, except share data)

   March 31,
2009
    December 31,
2008
 
     (Unaudited)        
ASSETS     

Current Assets:

    

Cash and cash equivalents

   $ 11,358     $ 11,513  

Accounts receivable, less allowance for doubtful accounts of $1,680 and $1,552 at March 31, 2009 and December 31, 2008, respectively; March 31, 2009 and December 31, 2008 include $121 and $72 due from I-Flow, respectively

     4,636       4,168  

Inventory supplies

     432       391  

Prepaid expenses and other current assets

     1,026       676  
                

Total Current Assets

     17,452       16,748  

Property & equipment, net

     10,833       10,878  

Deferred debt issuance costs, net

     1,133       1,276  

Goodwill

     56,580       56,580  

Intangible assets, net

     30,282       30,738  
                

Total Assets

   $ 116,280     $ 116,220  
                

LIABILITIES AND STOCKHOLDERS’ EQUITY

    

Current Liabilities:

    

Accounts payable

   $ 1,368     $ 1,012  

Deferred income taxes

     55       55  

Other current liabilities

     1,069       939  

Derivative liabilities

     5,235       2,592  

Current portion of long-term debt; both March 31, 2009 and December 31, 2008 include $8,564 payable to I-Flow

     8,645       8,644  
                

Total Current Liabilities

     16,372       13,242  

Long-term debt, net of current portion; March 31, 2009 and December 31, 2008 include $20,868 and $21,685 payable to I-Flow, respectively

     21,185       22,025  

Deferred income taxes

     880       880  
                

Total Liabilities

   $ 38,437     $ 36,147  
                

Stockholders’ Equity

    

Preferred stock, $.0001 par value: authorized 1,000,000
shares; none issued

     —         —    

Common stock, $.0001 par value; authorized 200,000,000
shares; issued 18,537,671 and 18,512,671, respectively; outstanding 18,537,671 and 17,278,626, respectively

     2       2  

Additional paid-in capital

     81,069       80,792  

Retained deficit

     (3,228 )     (721 )
                

Total Stockholders’ Equity

     77,843       80,073  
                

Total Liabilities and Stockholders’ Equity

   $ 116,280     $ 116,220  
                


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

(UNAUDITED)

 

     Three Months Ended March 31  

(in thousands, except per share data)

   2009     2008  

Net revenues

   $ 9,227     $ 8,530  

Operating expenses:

    

Cost of Revenues – Product and supply costs

     1,270       1,465  

Cost of Revenues – Pump depreciation

     840       963  

Provision for doubtful accounts

     969       861  

Amortization of intangibles

     457       457  

Selling and marketing

     1,320       1,077  

General and administrative

     3,110       3,186  
                

Total Operating Expenses

     7,966       8,009  
                

Operating income

     1,261       521  

Other (loss) income:

    

(Loss) gain on derivatives

     (2,642 )     5,231  

Interest income

     3       3  

Interest expense

     (989 )     (958 )
                

Total other (loss) income

     (3,628 )     4,276  
                

(Loss) income before income taxes

     (2,367 )     4,797  

Income tax expense

     (140 )     —    
                

Net (loss) income

     (2,507 )     4,797  
                

Net (loss) income per share:

    

Basic & Diluted

     (0.14 )     0.29  

Weighted average shares outstanding:

    

Basic & Diluted

     18,531,838       16,824,295  


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(UNAUDITED)

 

     Three Months Ended March 31  

(in thousands)

   2009     2008  

OPERATING ACTIVITIES

    

Net (Loss) Income

   (2,507 )   4,797  

Adjustments to reconcile net (loss) income to net cash provided by operating activities:

    

Loss (gain) on derivative liabilities

   2,642     (5,231 )

Provision for doubtful accounts

   969     861  

Depreciation

   872     1,004  

Amortization of intangible assets

   457     457  

Amortization of deferred debt issuance costs

   143     180  

Loss on disposal of assets

   109     225  

Stock-based compensation

   278     —    

Changes in current assets and liabilities:

    

(Increase) decrease in accounts receivable, net of provision

   (1,437 )   187  

(Increase) decrease in prepaid expenses and other current assets

   (391 )   803  

Increase in accounts payable and other current liabilities

   134     140  
            

NET CASH PROVIDED BY OPERATING ACTIVITIES

   1,269     3,423  
            

INVESTING ACTIVITIES

    

Payment of deferred acquisition costs

   —       (97 )

Capital expenditures

   (586 )   (447 )

Proceeds from sale of property

   1     —    
            

NET CASH USED IN INVESTING ACTIVITIES

   (585 )   (544 )
            

FINANCING ACTIVITIES

    

Principal payments on term loan

   (818 )   (409 )

Principal payments on capital lease obligation

   (21 )   —    
            

NET CASH USED IN FINANCING ACTIVITIES

   (839 )   (409 )
            

Net change in cash and cash equivalents

   (155 )   2,470  

Cash and cash equivalents, beginning of period

   11,513     3,960  
            

Cash and cash equivalents, end of period

   11,358     6,430