Exhibit 99.1

LOGO

For Immediate Release

Investors:

David K. Waldman or Klea K. Theoharis

Crescendo Communications, LLC

Tel: (212) 671-1020

InfuSystem Holdings Reports 12.9% Revenue Increase and

$3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008

Madison Heights, Michigan—March 3, 2009 – InfuSystem Holdings, Inc. (OTCBB: INHI; INHIW; INHIU), the leading provider of ambulatory infusion pumps and associated clinical services, today announced financial results and provided a business update for the fourth quarter ended December 31, 2008.

Mr. Steve Watkins, chief executive officer, commented, “We are pleased to report a 12.9% increase in revenue to $9.1 million for the fourth quarter of 2008, versus the comparable period in 2007 (which included the results of InfuSystem, Inc. under its prior ownership and InfuSystem Holdings as a stand-alone entity). Initiatives put in place earlier this year continue to fuel our growth and market penetration. These included enhanced sales training, restructured sales incentive programs and realigned sales territories to maximize coverage. As a result, we have succeeded in gaining market share and adding managed care contracts. We also continue to generate strong cash flow and increased cash reserves. During the fourth quarter, we achieved adjusted EBITDA of $3.3 million and had approximately $11.5 million of cash and cash equivalents as of December 31, 2008, allowing us to maintain a solid foundation during the current economic environment.”

“InfuSystem’s leading market position, favorable sales trends and improved operational efficiencies bode extremely well for 2009. Looking ahead, we see organic growth continuing in 2009, as physicians further expand the use of continuous infusion pumps to administer chemotherapy for other cancers in addition to stage III colorectal cancer. We have also built a highly scalable business model as a result of our national managed care contracts covering over 150 million lives and relationships with more than 60% of oncologist practices nationwide. We have made it a priority to leverage this extensive network by distributing complementary products and introducing key new services in 2009.”

Financial Results

Revenue for the fourth quarter ended December, 31 2008 was $9.1 million, versus $6.6 million for the same period in 2007. Revenue for the fourth quarter of 2007 reflects the revenues recognized by InfuSystem Holdings, Inc. following the acquisition of InfuSystem, Inc. from I-Flow Corporation on October 25, 2007. The increase in revenue reflects the full quarter of reported revenue in 2008 versus a partial quarter in 2007, and revenue growth for the comparable 67 day period in which InfuSystem was a standalone entity.


Operating income for the fourth quarter of 2008 was $1.5 million versus an operating income of $1.0 million for the same period in 2007. The increase in operating income for the fourth quarter of 2008 reflects the full quarter of revenue and operating expenses recorded for InfuSystem, Inc. in the fourth quarter of 2008 and improved operating income for the comparable periods in which InfuSystem was a standalone entity.

The net income for the fourth quarter of 2008 was $1.3 million, or $0.07 per diluted share, compared to net loss of ($1.9 million) or $(0.11) per diluted share, for the same period in 2007. The net income for the fourth quarter of 2008 included a $1.1 million gain on derivative financial instruments, which is predominantly attributable to the decrease in the publicly traded value of the Company’s warrants during the quarter, compared to a ($2.6 million) loss for the fourth quarter of 2007. The fourth quarter of 2007 also included a $0.3 million charge for stock-based compensation, $0.8 million of expenses related to the acquisition of InfuSystem, Inc., and a $0.3 million gain from interest income.

Adjusted EBITDA for the fourth quarter ended December, 31 2008 was $3.3 million. Adjusted EBITDA is not provided for the fourth quarter ended December 31, 2007. As Adjusted EBITDA is a measure of operating performance, and as that time period was made up of 25 days as a pre-acquisition shell company and 67 days as an operating entity, Adjusted EBITDA would not be meaningful. The Company defines Adjusted EBITDA as earnings before interest, taxes, depreciation and amortization, and excludes gain (loss) on derivative financial instruments, and stock-based compensation. Adjusted EBITDA is not a measure of performance calculated in accordance with generally accepted accounting principles in the United States (“GAAP”). The Company believes the presentation of Adjusted EBITDA is relevant and useful by enhancing the readers’ ability to understand the Company’s operating performance. The Company’s management utilizes Adjusted EBITDA as a means to measure operating performance. The table below reconciles Adjusted EBITDA, a non-GAAP measure, to net income for the three months and year ended December 31, 2008.

 

(in thousands)             

Reconciliation from Net Income to Adjusted EBITDA:

   Year Ended
December 31, 2008
    Three Months Ended
December 31, 2008
 

Net Income

   $ 9,959     $ 1,259  

Adjustments:

    

Interest expense

     3,771       943  

Interest income

     (36 )     (22 )

Income tax expense

     907       508  

Depreciation — Pumps

     3,769       861  

Depreciation — Other

     166       33  

Amortization

     1,827       457  
                

EBITDA

   $ 20,363     $ 4,039  

Adjustments:

    

Gain on derivatives

     (9,815 )     (1,150 )

Stock based compensation

     1,550       384  
                

Adj. EBITDA

   $ 12,098     $ 3,273  
                


About InfuSystem Holdings, Inc.

InfuSystem is the leading provider of ambulatory infusion pumps and associated clinical services for oncology practices and their patients in the U.S. These pumps allow for the gradual delivery of a drug over a period of days in the privacy of one’s home, compared to bolus infusion chemotherapy treatments that are given in a single high dose over a short period of time. Improved efficacy of the drugs, patient comfort, reimbursement to doctors for appropriate services and continuity of care all play a role in the growing trend toward this form of treatment. InfuSystem’s pumps are primarily used for colorectal cancer, but they have been approved for other forms of cancer, thereby greatly enhancing the market opportunity for InfuSystem.

Forward-Looking Statements

Except for the historical information contained herein, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties that could cause actual results to differ materially from those predicted by such forward-looking statements. These risks and uncertainties include general economic conditions, as well as other risks detailed from time to time in InfuSystem’s publicly filed documents.

(Tables follow)


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED BALANCE SHEETS

 

(in thousands, except share data)

   December 31,
2008
    December 31,
2007
 

ASSETS

    

Current Assets:

    

Cash and cash equivalents

   $ 11,513     $ 3,960  

Accounts receivable, less allowance for doubtful accounts of $1,552 and $1,638 at December 31, 2008 and 2007, respectively; December 31, 2008 and 2007 include $72 and $103 due from I-Flow, respectively

     4,168       6,304  

Inventory supplies

     391       364  

Prepaid expenses and other current assets

     676       1,263  

Deferred income taxes

     —         4  
                

Total Current Assets

     16,748       11,895  

Property & equipment, net

     10,878       13,504  

Deferred debt issuance costs, net

     1,276       1,918  

Goodwill

     56,580       56,544  

Intangible assets, net

     30,738       32,565  
                

Total Assets

   $ 116,220     $ 116,426  
                

LIABILITIES AND STOCKHOLDERS’ EQUITY

    

Current Liabilities:

    

Accounts payable

   $ 1,012     $ 1,076  

Deferred income taxes

     55       —    

Other current liabilities

     939       1,886  

Derivative liabilities

     2,592       12,407  

Current portion of long-term debt; December 31, 2008 and 2007 include $8,565 and $2,044 payable to I-Flow, respectively

     8,644       2,044  
                

Total Current Liabilities

     13,242       17,413  

Long-term debt, net of current portion; December 31, 2008 and 2007 include $21,685 and $30,250 payable to I-Flow, respectively

     22,025       30,250  

Deferred income taxes

     880       4  
                

Total Liabilities

   $ 36,147     $ 47,667  
                

Commitments and Contingencies

     —         —    

Stockholders’ Equity

    

Preferred stock, $.0001 par value: authorized 1,000,000 shares; none issued

     —         —    

Common stock, $.0001 par value; authorized 200,000,000 shares; issued 18,512,670 and 18,315,430, respectively; outstanding 17,278,626 and 16,824,295, respectively

     2       2  

Additional paid-in capital

     80,792       79,437  

Retained deficit

     (721 )     (10,680 )
                

Total Stockholders’ Equity

     80,073       68,759  
                

Total Liabilities and Stockholders’ Equity

   $ 116,220     $ 116,426  
                


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

 

(in thousands, except share and per share data)

   Year Ended
December 31,
2008
    Year Ended
December 31,
2007
 

Net revenues

   $ 35,415     $ 6,582  

Operating expenses:

    

Cost of revenues – Product and supply costs

     5,422       923  

Cost of revenues – Pump depreciation

     3,769       697  

Provision for doubtful accounts

     3,187       584  

Amortization of intangibles

     1,827       335  

Selling and marketing

     4,659       649  

General and administrative

     11,765       4,891  
                

Total Operating Expenses

     30,629       8,079  
                

Operating income (loss)

     4,786       (1,497 )

Other income (expense):

    

Gain (loss) on derivatives

     9,815       (3,294 )

Interest income

     36       3,879  

Interest expense

     (3,771 )     (774 )
                

Total other income (expense)

     6,080       (189 )
                

Income (loss) before income taxes

     10,866       (1,686 )

Income tax expense

     (907 )     (1,110 )
                

Net income (loss)

   $ 9,959     $ (2,796 )
                

Net income (loss) per share:

    

Basic

   $ 0.56     $ (0.15 )

Diluted

   $ 0.53     $ (0.15 )

Weighted average shares outstanding:

    

Basic

     17,940,952       18,299,600  

Diluted

     18,672,321       18,299,600  


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

 

(in thousands, except share and per share data)

   Three Months Ended
December 31, 2008
 

Net revenues

   $ 9,092  

Operating expenses:

  

Cost of Revenues — Product and supply costs

     1,240  

Cost of Revenues — Pump depreciation

     861  

Provision for doubtful accounts

     710  

Amortization of intangibles

     457  

Selling and marketing

     1,258  

General and administrative

     3,028  
        

Total Operating Expenses

     7,554  
        

Operating income

     1,538  

Other income (expense):

  

Gain on derivatives

     1,150  

Interest income

     22  

Interest expense

     (943 )
        

Total other income

     229  
        

Income before income taxes

     1,767  

Income tax expense

     (508 )
        

Net income

     1,259  
        

Net income per share:

  

Basic

     0.07  

Diluted

     0.07  

Weighted average shares outstanding:

  

Basic

     18,476,445  

Diluted

     18,794,943  

(in thousands, except share and per share data)

   Three Months Ended
December 31, 2007
 

Net revenues

   $ 6,582  

Operating expenses

     (5,618 )
        

Operating income

     964  

Other expense

     (2,475 )
        

Loss before income taxes

     (1,511 )

Income tax expense

     (357 )
        

Net loss

     (1,868 )
        

Net loss per share:

  

basic

     (0.11 )

diluted

     (0.11 )

Weighted average shares outstanding:

  

basic

     17,333,261  

diluted

     17,333,261  


INFUSYSTEM HOLDINGS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

 

(in thousands)

   Year Ended
December 31,
2008
    Year Ended
December 31,
2007
 

OPERATING ACTIVITIES

    

Net Income (Loss)

   $ 9,959     $ (2,796 )

Adjustments to reconcile net income (loss) to net cash provided by operating activities:

    

(Gain) loss on derivative liabilities

     (9,815 )     3,294  

Depreciation

     3,935       728  

Provision for doubtful accounts

     3,187       584  

Amortization of intangible assets

     1,827       335  

Stock-based compensation

     1,550       1,750  

Amortization of deferred debt issuance costs

     642       134  

Loss on disposal of assets

     553       107  

Deferred income taxes

     935       —    

Withdrawal of interest earned on investments held in trust

     —         5,815  

Interest income on investments held in trust

     —         (3,879 )

Changes in current assets and liabilities, net of effects of acquisitions:

    

Increase in accounts receivable, net of provision

     (1,835 )     (698 )

Decrease (increase) in prepaid expenses and other current assets

     560       (431 )

Decrease in accounts payable and other current liabilities

     (601 )     (566 )
                

NET CASH PROVIDED BY OPERATING ACTIVITIES

     10,897       4,377  
                

INVESTING ACTIVITIES

    

Capital expenditures

     (1,733 )     (553 )

Payment of deferred acquisition costs

     (105 )     (8,690 )

Proceeds from sale of property

     10       —    

Cash from trust, excluding interest earned

     —         96,215  

Cash received (paid) for acquisition from (to) I-Flow, net of cash acquired

     784       (64,954 )
                

NET CASH (USED IN) PROVIDED BY INVESTING ACTIVITIES

     (1,044 )     22,018  
                

FINANCING ACTIVITIES

    

Principal payments on term loan

     (2,044 )     (409 )

Common stock repurchased to satisfy minimum statutory withholding on stock-based compensation

     (195 )     —    

Principal payments on capital lease obligation

     (61 )     —    

Share conversion payments to stockholders

     —         (16,359 )

Capitalized debt issuance costs

     —         (2,052 )

Payment to FTN Midwest of deferred underwriting fees

     —         (4,555 )

Proceeds from issuance of warrants

     —         513  
                

NET CASH USED IN FINANCING ACTIVITIES

     (2,300 )     (22,862 )
                

Net change in cash and cash equivalents

     7,553       3,533  

Cash and cash equivalents, beginning of period

     3,960       427  
                

Cash and cash equivalents, end of period

   $ 11,513     $ 3,960