Exhibit 99.1

LOGO

For Immediate Release

Investors:

David K. Waldman or Klea K. Theoharis

Crescendo Communications, LLC

Tel: (212) 671-1020

InfuSystem Holdings Reports 14.5% Revenue Increase and

Approximately $3.6 Million of Adjusted EBITDA for the Third Quarter of 2008

Madison Heights, Michigan—November 5, 2008 – InfuSystem Holdings, Inc. (OTCBB: INHI; INHIW; INHIU), the leading provider of ambulatory infusion pumps and associated clinical services, today announced financial results and provided a business update for the third quarter ended September 30, 2008.

Mr. Steve Watkins, chief executive officer, commented, “We are pleased to report a solid 14.5% increase in revenue for the third quarter of 2008, compared to the results of InfuSystem, Inc. for the same period last year, while under its prior ownership. Since our acquisition of InfuSystem, Inc. during the fourth quarter of 2007, we have generated very strong cash flow. During the third quarter alone, we achieved $3.6 million of adjusted EBITDA and now have approximately $10.8 million of cash and cash equivalents as of September 30, 2008.”

“During the third quarter, we signed agreements with 9 new managed care organizations. Our increasing number of contracts and covered lives is further evidence of our overall market penetration and acceptance. We are the only nationwide provider of ambulatory infusion pumps with contracts in place with most national and regional insurance providers. We see this as a significant competitive advantage, since physicians prefer to work with a single provider that can accept insurance from most or all of their patients. Other competitive advantages include: our vast pump selection; our nationwide sales force; and most importantly, our 24-hour staffed nurse hotline for patient questions and assistance. Given these strengths, we continue to explore acquisitions and strategic partnerships that should enable us to expand our product and service offering in order to leverage our deep penetration into oncologist practices across the U.S.”

Mr. Watkins concluded, “We are also continuing to make headway on a number of operational initiatives designed to boost revenue and enhance efficiency within the organization. These initiatives include upgraded computer systems and software to: support our sales initiatives; improve inter-departmental communication; and streamline billing. In response to our customers’ requests, we have also implemented an on-line ordering system whereby oncology practices can order pumps directly through our website. This simplifies the ordering process for our customers while providing operational benefits to our company.”


Financial Results

Revenue for the third quarter ended September 30, 2008 was $9.0 million, versus $0 for the same period in 2007, which reflects the revenues recognized by InfuSystem Holdings, Inc. following the acquisition of InfuSystem, Inc. from I-Flow Corporation.

Operating income for the third quarter of 2008 was $1.6 million versus an operating loss of ($699,000) for the same period in 2007. The increase in operating income for the third quarter of 2008 reflects revenue and operating expenses recorded for InfuSystem, Inc. following the acquisition.

The net income for the third quarter of 2008 was $5.7 million, or $0.30 per diluted share, compared to net loss of ($505,000) or $(0.03) per diluted share, for the same period in 2007. The net income for the third quarter of 2008 included a $5.4 million gain on derivative financial instruments, which is predominantly attributable to the decrease in the publicly traded value of the Company’s warrants during the quarter, compared to a ($675,000) loss for the third quarter of 2007.

Adjusted EBITDA for the third quarter ended September 30, 2008 was $3.6 million, as compared to an Adjusted EBITDA loss of approximately ($435,000) for the same period of 2007. The Company defines Adjusted EBITDA as earnings before interest, taxes, depreciation and amortization, and excludes gain (loss) on derivative financial instruments, and stock-based compensation. Adjusted EBITDA is not a measure of performance calculated in accordance with accounting principles generally accepted in the United States (“GAAP”), and should not be considered in isolation of, or as a substitute for, earnings as an indicator of operating performance, or cash flows from operating activities as a measure of liquidity. The Company believes the presentation of Adjusted EBITDA is relevant and useful by enhancing the readers’ ability to understand the Company’s operating performance. The Company’s management utilizes Adjusted EBITDA as a means to measure performance. The Company’s measurements of Adjusted EBITDA may not be comparable to similarly titled measures reported by other companies. The tables below reconcile Adjusted EBITDA, a non-GAAP measure, to net income for the three and nine months ended September 30, 2008 and 2007.


Reconciliation from Net Income to Adjusted EBITDA:

 

     Three Months Ended September 30  

(in thousands, except per share data)

 

   2008     2007           I-Flow
Predecessor
2007
 

Net Income

   $ 5,704     $ (505 )        $ 1,308  

Adjustments:

           

Interest expense

     937       18            —    

Interest income

     (11 )     (1,210 )          —    

Income tax expense

     399       323            936  

Depreciation - Pumps

     978       —              1,032  

Depreciation - Other

     47       —              39  

Amortization

     456       —              —    
                             

EBITDA

   $ 8,511     $ (1,374 )        $ 3,315  

Adjustments:

           

(Gain) loss on derivatives

     (5,381 )     675            —    

Stock based compensation

     479       264            159  
                             

Adj. EBITDA

   $ 3,609     $ (435 )        $ 3,474  
                             
 

Adj. EBITDA EPS - basic

     0.20       (0.02 )          N/A  

Adj. EBITDA EPS - diluted

     0.19       (0.02 )          N/A  
 
Reconciliation from Net Income to Adjusted EBITDA:            

(in thousands, except per share data)

 

   Nine Months Ended September 30  
   2008     2007           I-Flow
Predecessor

2007
 

Net Income

   $ 8,700     $ (928 )        $ 3,604  

Adjustments:

           

Interest expense

     2,828       33            (237 )

Interest income

     (14 )     (3,534 )          —    

Income tax expense

     399       752            2,460  

Depreciation - Pumps

     2,908       —              2,307  

Depreciation - Other

     133       —              125  

Amortization

     1,370       —              —    
                             

EBITDA

   $ 16,325     $ (3,677 )        $ 8,259  

Adjustments:

           

(Gain) loss on derivatives

     (8,665 )     675            —    

Stock based compensation

     1,166       1,490            305  
                             

Adj. EBITDA

   $ 8,826     $ (1,512 )        $ 8,564  
                             
 

Adj. EBITDA EPS - basic

     0.50       (0.08 )          N/A  

Adj. EBITDA EPS - diluted

     0.47       (0.08 )          N/A  

About InfuSystem Holdings, Inc.

InfuSystem is the leading provider of ambulatory infusion pumps and associated clinical services for oncology practices and their patients in the U.S. These pumps allow for the gradual delivery of a drug over a period of days in the privacy of one’s home, compared to bolus infusion chemotherapy treatments that are given in a single high dose over a short period of time. Improved efficacy of the drugs, patient comfort, reimbursement to doctors for appropriate services and continuity of care all play a role in the growing trend toward this form of treatment. InfuSystem’s pumps are primarily used for colorectal cancer, but they have been approved for other forms of cancer, thereby greatly enhancing the market opportunity for InfuSystem.


Forward-Looking Statements

Except for the historical information contained herein, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties that could cause actual results to differ materially from those predicted by such forward-looking statements. These risks and uncertainties include general economic conditions, as well as other risks detailed from time to time in InfuSystem’s publicly filed documents.

(Tables follow)


InfuSystem Holdings, Inc.

CONSOLIDATED BALANCE SHEETS

 

(in thousands, except share data)

 

   September 30,
2008
    December 31,
2007
 
     (Unaudited)        

ASSETS

    

Current Assets:

    

Cash and cash equivalents

   10,795     3,960  

Accounts receivable, less allowance for doubtful accounts of $1,935 and $1,638 at September 30, 2008 and December 31, 2007, respectively; September 30, 2008 and December 31, 2007 include $40 and $103 due from I-Flow, respectively

   4,132     6,304  

Inventory supplies

   397     364  

Prepaid expenses and other current assets

   394     1,263  

Deferred income taxes

   4     4  
            

Total Current Assets

   15,722     11,895  

Property & equipment, net

   11,232     13,504  

Deferred debt issuance costs, net

   1,424     1,918  

Deferred Income Taxes

   —       —    

Goodwill

   56,580     56,544  

Intangible assets, net

   31,195     32,565  
            

Total Assets

   116,153     116,426  
            

LIABILITIES AND STOCKHOLDERS’ EQUITY

    

Current Liabilities:

    

Accounts payable

   1,213     1,076  

Other current liabilities

   776     1,886  

Derivative liabilities

   3,742     12,407  

Current portion of long-term debt; September 30, 2008 and December 31, 2007 include $3,270 and $2,044 payable to I-Flow, respectively

   3,348     2,044  
            

Total Current Liabilities

   9,079     17,413  

Long-term debt, net of current portion; September 30, 2008 and December 31, 2007 include $27,798 and $30,250 payable to I-Flow, respectively

   28,159     30,250  

Deferred income taxes

   403     4  
            

Total Liabilities

   37,641     47,667  
            

Stockholders’ Equity

    

Preferred stock, $.0001 par value: authorized 1,000,000 shares; none issued

   —       —    

Common stock, $.0001 par value; authorized 200,000,000 shares; issued 18,426,421 and 18,315,430, respectively; outstanding 17,192,377 and 16,824,295, respectively

   2     2  

Additional paid-in capital

   80,490     79,437  

Retained deficit

   (1,980 )   (10,680 )
            

Total Stockholders’ Equity

   78,512     68,759  
            

Total Liabilities and Stockholders’ Equity

   116,153     116,426  
            


InfuSystem Holdings, Inc.

CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)

 

     Three Months Ended September 30,     Nine Months Ended September 30,  

(in thousands, except per share data)

 

   2008     2007           I-Flow
Predecessor
2007
    2008     2007           I-Flow
Predecessor
2007
 

Net revenues

   $ 8,958     $ —            $ 7,822     $ 26,323     $ —            $ 23,528  
   

Operating expenses:

                      

Cost of Revenues - Product and supply costs

     1,340       —              1,159       4,182       —              3,746  

Cost of Revenues - Pump depreciation

     978       —              1,032       2,908       —              2,307  

Provision for doubtful accounts

     702       —              619       2,477       —              3,278  

Amortization of intangibles

     456       —              —         1,370       —              —    

Selling and marketing

     1,131       —              1,036       3,401       —              3,030  

General and administrative

     2,703       699            1,732       8,737       3,002            5,340  
                                                          

Total Operating Expenses

     7,310       699            5,578       23,075       3,002            17,701  
                                                          
   

Other income (expense):

                      

Gain (loss) on derivatives

     5,381       (675 )          —         8,665       (675 )          —    

Interest income

     11       1,210            —         14       3,534            —    

Interest expense

     (937 )     (18 )          —         (2,828 )     (33 )          237  
                                                          

Total other income

     4,455       517            —         5,851       2,826            237  
                                                          
   

Income (loss) before income taxes

     6,103       (182 )          2,244       9,099       (176 )          6,064  

Income tax expense

     (399 )     (323 )          (936 )     (399 )     (752 )          (2,460 )
                                                          

Net income (loss)

     5,704       (505 )          1,308       8,700       (928 )          3,604  
                                                          
   

Net income (loss) per share:

                      

Basic

     0.31       (0.03 )          N/A       0.49       (0.05 )          N/A  

Diluted

     0.30       (0.03 )          N/A       0.47       (0.05 )          N/A  

Weighted average shares outstanding:

                      
   

Basic

     18,442,957 *     18,625,252            N/A       17,757,075 *     18,625,252            N/A  
   

Diluted

     18,794,182       18,625,252            N/A       18,581,789       18,625,252            N/A  

 

* Includes, from April 25, 2008, the 1,234,044 shares referenced in Notes 9 and 10 to our Consolidated Financial Statements included in this Quarterly Report on Form 10-Q.


InfuSystem Holdings, Inc.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

 

(in thousands)

 

   Nine Months Ended September 30,  
   2008     2007           I-Flow
Predecessor
2007
 

OPERATING ACTIVITIES

           

Net Income (Loss)

     8,700       (928 )          3,604  
 

Items included in net income not requiring cash:

           

(Gain) loss on derivative liabilities

     (8,665 )     675            —    

Provision for doubtful accounts

     2,477       —              3,278  

Depreciation

     3,041       —              2,432  

Amortization of intangible assets

     1,370       —              —    

Amortization of deferred debt issuance costs

     494       —              —    

Loss on disposal of assets

     385       —              241  

Interest Income on Investments Held in Trust

     —         (3,528 )          —    

Withdrawal of interest earned on investments held in trust

     —         422            —    

Stock-based compensation

     1,166       1,490            305  

Deferred Income Taxes

     399       —              (517 )

Changes in current assets and liabilities:

           

Decrease (increase) in accounts receivable

     (305 )     —              (1,636 )

Decrease (increase) in prepaid expenses and other current assets

     836       439            (129 )

(Decrease) increase in accounts payable and other current liabilities

     (628 )     768            (953 )
                             

NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES

     9,270       (662 )          6,625  
                             
 

INVESTING ACTIVITIES

           

Payment of deferred acquisition costs

     (105 )     (252 )          —    

Capital expenditures

     (951 )     —              (2,664 )

Proceeds from sale of property

     —         —              231  
                             

NET CASH USED IN INVESTING ACTIVITIES

     (1,056 )     (252 )          (2,433 )
                             
 

FINANCING ACTIVITIES

           

Net capital distributions to parent

     —         —              (5,147 )

Principal payments on term loan

     (1,226 )     —              —    

Common stock repurchased to satisfy minimum statutory

     (113 )     —              —    

withholding on stock-based compensation

           

Principal payments on capital lease obligation

     (40 )     —              —    

Proceeds from issuance of warrants

     —         514            —    
                             

NET CASH (USED IN) PROVIDED BY FINANCING ACTIVITIES

     (1,379 )     514            (5,147 )
                             

Net change in cash and cash equivalents

     6,835       (400 )          (955 )

Cash and cash equivalents, beginning of period

     3,960       427            1,956  
                             

Cash and cash equivalents, end of period

     10,795       27            1,001  
                             
 

SUPPLEMENTAL DISCLOSURES

           

Cash paid for interest (including swap payments/proceeds, and excluding capitalized interest)

   $ 2,334     $ 4          $ —    

Cash paid for income taxes

   $ 478     $ 695          $ 186  

NON-CASH TRANSACTIONS

           

Additions to property

   $ 80     $ —            $ 241  

Property acquired with a capital lease

   $ 480     $ —            $ —    

Issuance of vested restricted shares (number of shares)

     150       —              —    

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