FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Dilorio Richard
   2. Issuer Name and Ticker or Trading Symbol
InfuSystem Holdings, Inc [INFU] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President & CEO
(Last)
(First)
(Middle)
3851 WEST HAMLIN ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
01/20/2022
(Street)

ROCHESTER HILL, MI 48309		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 01/20/2022   M   15,936 A $ 1.98 255,771 (1) D  
Common Stock 01/20/2022   S(2)   15,936 D $ 15.98 (3) 239,835 D  
Common Stock 01/21/2022   M   9,064 A $ 1.98 248,899 D  
Common Stock 01/21/2022   S(2)   9,064 D $ 15.52 (3) 239,835 D  
Common Stock 01/21/2022   M   149 A $ 2 239,984 D  
Common Stock 01/21/2022   S(2)   149 D $ 15.52 (3) 239,835 D  
Common Stock 01/24/2022   M   33,519 A $ 2 273,354 D  
Common Stock 01/24/2022   S(2)   33,519 D $ 15.41 (3) 239,835 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 1.98 01/20/2022   M     15,936 09/07/2018 09/07/2022 Common Stock 15,936 $ 0 9,064 D  
Stock Option (right to buy) $ 1.98 01/21/2022   M     9,064 09/07/2018 09/07/2022 Common Stock 9,064 $ 0 0 D  
Stock Option (right to buy) $ 2 01/21/2022   M     149 12/15/2017 11/15/2022 Common Stock 149 $ 0 199,851 D  
Stock Option (right to buy) $ 2 01/24/2022   M     33,519 12/15/2017 11/15/2022 Common Stock 33,519 $ 0 166,332 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Dilorio Richard
3851 WEST HAMLIN ROAD
ROCHESTER HILL, MI 48309		   X     President & CEO  

Signatures

 /s/ Kevin Whitman, Attorney-in-Fact for Richard Dilorio   01/24/2022
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This total includes 78 shares acquired recently through the Company's Employee Stock Purchase Plan.
(2) The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the reporting person.
(3) The price reported in Column 4 is a weighted average price. These shares reported herein were sold in multiple transactions. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

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